Biography

Peter I. Lelkes, PhD, is the Laura H. Carnell Professor and Founding Chair of the Department of Bioengineering in the College of Engineering at Temple University. Dr. Lelkes is also the Inaugural Director of the Institute for Regenerative Medicine and Engineering (TIME) at Temple University's School of Medicine. Prior to that he was from 2000-2011 the Calhoun Chair Professor in the School of Biomedical Engineering, Science and Health Systems at Drexel University in Philadelphia.

Dr. Lelkes has received numerous honors and awards, nationally and internationally. Amongst them a Forchheimer Visiting Fellowship at the Hebrew University, Jerusalem, Honorary Professorships at the University of Applied Sciences Aachen, Germany and the Changchun Institute of Polymer Chemistry and Physics, Chinese Academy of Sciences, and a Distinguished Visiting Fellowship of the Royal Academy of Engineering at Imperial College, London, UK. In 2011 he was inducted as a Fellow of the AIMBE (American Institute for Medical and Biological Engineering) and received the 2012 Ben Franklin Key Award from IEEE, the Institute of Electrical and Electronics Engineers.

Throughout his career of 30+ years, Dr. Lelkes has received over $18 million in funding from numerous federal and private funding sources. Dr. Lelkes has organized several Keystone conferences, published more than 175 peer-reviewed papers, authored more than 50 books / book chapters and made more than 400 presentations nationally and internationally.

In his free-time Dr. Lelkes is an active chamber musician and likes to hike in the mountains.

Research Interests

  • Regenerative Tissue Engineering
  • Nanotechnology-Based Biomaterials
  • Soft Tissue Engineering
  • Tissue-Specific Differentiation of Embryonic & Adult Stem Cells Towards Pulmonary, Cardiac & Neuronal Lineages
  • Absorbable Bone Fixation and Regenerative Repair Technologies

Courses Taught

Number

Name

Level

BIOE 0944

Honors Bionic Human

Undergraduate

BIOE 4501

Capstone Elective: Regenerative Engineering

Undergraduate

BIOE 5501

Regenerative Engineering

Graduate

Selected Publications

Recent

  • Licata, J.P., Schwab, K.H., Har-El, Y., Gerstenhaber, J.A., & Lelkes, P.I. (2023). Bioreactor Technologies for Enhanced Organoid Culture. Int J Mol Sci, 24(14). Switzerland. doi: 10.3390/ijms241411427

  • Braveboy-Wagner, J. & Lelkes, P.I. (2022). Impairment of 7F2 osteoblast function by simulated partial gravity in a Random Positioning Machine. NPJ Microgravity, 8(1), p. 20. United States. doi: 10.1038/s41526-022-00202-x

  • Braveboy-Wagner, J., Sharoni, Y., & Lelkes, P.I. (2021). Nutraceuticals Synergistically Promote Osteogenesis in Cultured 7F2 Osteoblasts and Mitigate Inhibition of Differentiation and Maturation in Simulated Microgravity. Int J Mol Sci, 23(1). Switzerland. doi: 10.3390/ijms23010136

  • Montoya, C., Jain, A., Londoño, J.J., Correa, S., Lelkes, P.I., Melo, M.A., & Orrego, S. (2021). Multifunctional Dental Composite with Piezoelectric Nanofillers for Combined Antibacterial and Mineralization Effects. ACS Appl Mater Interfaces, 13(37), pp. 43868-43879. United States. doi: 10.1021/acsami.1c06331

  • Rubin, L., Stabler, C.T., Schumacher-Klinger, A., Marcinkiewicz, C., Lelkes, P.I., & Lazarovici, P. (2021). Neurotrophic factors and their receptors in lung development and implications in lung diseases. Cytokine Growth Factor Rev, 59, pp. 84-94. England. doi: 10.1016/j.cytogfr.2021.01.008

  • Montoya, C., Du, Y.u., Gianforcaro, A.L., Orrego, S., Yang, M., & Lelkes, P.I. (2021). On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook. Bone Res, 9(1), p. 12. China. doi: 10.1038/s41413-020-00131-z

  • Caires-Júnior, L.C., Goulart, E., Telles-Silva, K.A., Araujo, B.H.S., Musso, C.M., Kobayashi, G., Oliveira, D., Assoni, A., Carvalho, V.M., Ribeiro-Jr, A.F., Ishiba, R., Braga, K.A.O., Nepomuceno, N., Caldini, E., Rangel, T., Raia, S., Lelkes, P.I., & Zatz, M. (2021). Pre-coating decellularized liver with HepG2-conditioned medium improves hepatic recellularization. Mater Sci Eng C Mater Biol Appl, 121, p. 111862. Netherlands. doi: 10.1016/j.msec.2020.111862

  • Oss-Ronen, L., Redden, R.A., & Lelkes, P.I. (2020). Enhanced Induction of Definitive Endoderm Differentiation of Mouse Embryonic Stem Cells in Simulated Microgravity. Stem Cells Dev, 29(19), pp. 1275-1284. United States. doi: 10.1089/scd.2020.0097

  • Phelan, M.A., Kruczek, K., Wilson, J.H., Brooks, M.J., Drinnan, C.T., Regent, F., Gerstenhaber, J.A., Swaroop, A., Lelkes, P.I., & Li, T. (2020). Soy Protein Nanofiber Scaffolds for Uniform Maturation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium. Tissue Eng Part C Methods, 26(8), pp. 433-446. United States. doi: 10.1089/ten.TEC.2020.0072

  • Feuerstein, G.Z., Mansfield, M.A., Lelkes, P.I., Alesci, S., Marcinkiewicz, C., Butlin, N., & Sternberg, M. (2020). The Use of Near-Infrared Light-Emitting Fluorescent Nanodiamond Particles to Detect Ebola Virus Glycoprotein: Technology Development and Proof of Principle. Int J Nanomedicine, 15, pp. 7583-7599. New Zealand. doi: 10.2147/IJN.S261952

  • Marcinkiewicz, C., Lelkes, P.I., Sternberg, M., & Feuerstein, G.Z. (2020). Effects of Fluorescent Diamond Particles FDP-NV-800nm on Essential Biochemical Functions of Primary Human Umbilical Vein Cells and Human Hepatic Cell Line, HepG-2 in vitro (Part VI): Acute Biocompatibility Studies. Nanotechnol Sci Appl, 13, pp. 103-118. New Zealand. doi: 10.2147/NSA.S268107

  • Lazarovici, P., Marcinkiewicz, C., & Lelkes, P.I. (2020). Cell-Based Adhesion Assays for Isolation of Snake Venom's Integrin Antagonists. Methods Mol Biol, 2068, pp. 205-223. United States. doi: 10.1007/978-1-4939-9845-6_11

  • Goulart, E., Caires-Junior, L.C.d.e., Telles-Silva, K.A., Araujo, B.H.S., Rocco, S.A., Sforca, M., Sousa, I.L.d.e., Kobayashi, G.S., Musso, C.M., Assoni, A.F., Oliveira, D., Caldini, E., Raia, S., Lelkes, P.I., & Zatz, M. (2019). 3D bioprinting of liver spheroids derived from human induced pluripotent stem cells sustain liver function and viability in vitro. Biofabrication, 12(1), p. 015010. England. doi: 10.1088/1758-5090/ab4a30

  • Du, Y.u., Montoya, C., Orrego, S., Wei, X.i., Ling, J., Lelkes, P.I., & Yang, M. (2019). Topographic cues of a novel bilayered scaffold modulate dental pulp stem cells differentiation by regulating YAP signalling through cytoskeleton adjustments. Cell Prolif, 52(6), p. e12676. England. doi: 10.1111/cpr.12676

  • Goulart, E., Caires-Junior, L.C.d.e., Telles-Silva, K.A., Araujo, B.H.S., Kobayashi, G.S., Musso, C.M., Assoni, A.F., Oliveira, D., Caldini, E., Gerstenhaber, J.A., Raia, S., Lelkes, P.I., & Zatz, M. (2019). Adult and iPS-derived non-parenchymal cells regulate liver organoid development through differential modulation of Wnt and TGF-β. Stem Cell Res Ther, 10(1), p. 258. England. doi: 10.1186/s13287-019-1367-x

  • Phelan, M.A., Gianforcaro, A.L., Gerstenhaber, J.A., & Lelkes, P.I. (2019). An Air Bubble-Isolating Rotating Wall Vessel Bioreactor for Improved Spheroid/Organoid Formation. Tissue Eng Part C Methods, 25(8), pp. 479-488. United States. doi: 10.1089/ten.TEC.2019.0088

  • Malik, R., Luong, T., Cao, X., Han, B., Shah, N., Franco-Barraza, J., Han, L., Shenoy, V.B., Lelkes, P.I., & Cukierman, E. (2019). Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2. Matrix Biol, 81, pp. 50-69. Netherlands. doi: 10.1016/j.matbio.2018.11.001

  • Novosel, E., Borchers, K., Kluger, P.J., Mantalaris, A., Matheis, G., Pistolesi, M., Schneider, J., Wenz, A., & Lelkes, P.I. (2019). New Approaches to Respiratory Assist: Bioengineering an Ambulatory, Miniaturized Bioartificial Lung. ASAIO J, 65(5), pp. 422-429. United States. doi: 10.1097/MAT.0000000000000841

  • Phelan, M., Lelkes, P., & Swaroop, A. (2019). Customized rotating wall vessel bioreactors produce improved retinal organoids with reduced operational costs and less frequent experimental failure. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 60(9). Retrieved from http://gateway.webofknowledge.com/

  • Lazarovici, P., Marcinkiewicz, C., & Lelkes, P.I. (2019). From Snake Venom's Disintegrins and C-Type Lectins to Anti-Platelet Drugs. Toxins (Basel), 11(5). Switzerland. doi: 10.3390/toxins11050303

  • Gangolli, R.A., Devlin, S.M., Gerstenhaber, J.A., Lelkes, P.I., & Yang, M. (2019). A Bilayered Poly (Lactic-Co-Glycolic Acid) Scaffold Provides Differential Cues for the Differentiation of Dental Pulp Stem Cells. Tissue Eng Part A, 25(3-4), pp. 224-233. United States. doi: 10.1089/ten.TEA.2018.0041

  • Barone, F.C., Marcinkiewicz, C., Li, J., Feng, Y.i., Sternberg, M., Lelkes, P.I., Rosenbaum-Halevi, D., Gerstenhaber, J.A., & Feuerstein, G.Z. (2019). Long-term biocompatibility of fluorescent diamonds-(NV)-Z~800 nm in rats: survival, morbidity, histopathology, particle distribution and excretion studies (part IV). Int J Nanomedicine, 14, pp. 1163-1175. New Zealand. doi: 10.2147/IJN.S189048

  • Gerstenhaber, J.A., Marcinkiewicz, C., Barone, F.C., Sternberg, M., D'Andrea, M.R., Lelkes, P.I., & Feuerstein, G.Z. (2019). Biocompatibility studies of fluorescent diamond particles-(NV)~800nm (part V): in vitro kinetics and in vivo localization in rat liver following long-term exposure. Int J Nanomedicine, 14, pp. 6451-6464. New Zealand. doi: 10.2147/IJN.S209663